Tyrosine Phosphorylation of MAL in TLR4 Signaling and Endotoxin Tolerance
نویسندگان
چکیده
منابع مشابه
Temporal Dynamics of Tyrosine Phosphorylation in Insulin Signaling Running title: Tyrosine phosphorylation in insulin signaling
The insulin signaling network regulates blood glucose levels, controls metabolism, and when dysregulated, may lead to the development of type 2 diabetes. Although the role of tyrosine phosphorylation in this network is clear, only a limited number of insulininduced tyrosine phosphorylation sites have been identified. To address this issue and establish temporal response, we have, for the first ...
متن کاملCD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance.
Dimerization of Toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD2) heterodimers is critical for both MyD88- and TIR-domain-containing adapter-inducing IFN-β (TRIF)-mediated signaling pathways. Recently, Zanoni et al. [(2011) Cell 147(4):868-880] reported that cluster of differentiation 14 (CD14) is required for LPS-/Escherichia coli- induced TLR4 internalization into endosomes a...
متن کاملMyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.
Members of the Toll-like receptor (TLR) family are essential players in activating the host innate immune response against infectious microorganisms. All TLRs signal through Toll/interleukin 1 receptor domain-containing adapter proteins. MyD88 adapter-like (Mal) is one such adapter that specifically is involved in TLR2 and TLR4 signaling. When overexpressed we have found that Mal undergoes tyro...
متن کاملProtein tyrosine phosphorylation in T cell signaling.
This review discusses in considerable detail the tyrosine phosphorylation events that couple the T cell antigen receptor to downstream signaling pathways. First, the protein kinases that catalyze these tyrosine phosphorylation are introduced, then the phosphatases that mediate removal of phosphate from tyrosine residues. Next, we discuss the molecular clock work by which these enzymes initiated...
متن کاملTyrosine phosphorylation in plant cell signaling.
R protein phosphorylation is the most common mechanism for cellular regulation in eukaryotic systems. Studies have demonstrated that serine threonine phosphorylation plays a key role in the regulation of plant growth and development. On the other hand, tyrosine phosphorylation, despite its overwhelming importance in animals, has been largely neglected because a typical tyrosine kinase was not f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.672.26